New perspectives on PPAR, VDR and FXR? as new actors in testicular pathophysiology
نویسندگان
چکیده
The incidence of reproductive disorders is constantly increasing and affects 15% couples, with male's abnormalities diagnosed in almost half the cases. male gonads exert two major functions testis productions gametes (exocrine function) sexual hormones (endocrine function). In last decades, next to steroid receptors such as estrogen androgen receptors, involvement other members nuclear receptor superfamily have been described Steroidogenic factor-1 (SF-1), Nerve growth factor IB (NGFIB), Liver-X-Receptor? (LXR?) Dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1 (DAX-1). purpose this review highlight emerging roles some among which vitamin-D Receptor (VDR), Peroxisome Proliferator-Activated (PPAR), Farnesoid-X-Receptor-? (FXR?). We discuss how these could participate explain fertility disorders; their potential be use biomarkers or therapeutic targets for management disorders.
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ژورنال
عنوان ژورنال: Molecular Aspects of Medicine
سال: 2021
ISSN: ['1872-9452', '0098-2997']
DOI: https://doi.org/10.1016/j.mam.2020.100886